The structure modeling was performed using the I-TASSER server (as “Zhang Server”), which consists of multiple threading alignments and iterative template fragment assembly simulations18 (link)34 (link). The I-TASSER program was ranked as the best server in the Critical Assessment of protein Structure Prediction experiments. The server generates the most accurate structural predictions via a state-of the-art process. The quality of the predicted structures was evaluated by a confidence score (C-score), and a C-score of >−1.5 denotes a correct fold. The template modeling score (TM-score) describes the topological similarity between the predicted model and the native structure. A TM-score of >0.5 indicates protein pairs with similar folds as well as a more accurate model prediction18 (link). The amino acid sequence of the WSTF PHD_EL5 RING finger (Figure 1) was subjected to the I-TASSER server, and the obtained structure was validated using PROCHECK23 . The program Discovery Studio 2.1, San Diego: Accelrys Software Inc., was used to calculate the Connolly surface and prepare drawings of the structures32 (link).