Pluronic/Soluplus Mixed Micelles for VES-GEM Delivery

The effect of co-surfactant Soluplus^® was tested by preparing a series of Pluronic^®/Soluplus^®@VES-GEM mixed micelles with a varying Pluronic^® molar ratio and decreasing Pluronic^® F68 and Pluronic^® F127 concentration to compensate for the addition of the co-surfactant. Briefly, Pluronic F68^®/Soluplus^®@VES-GEM mixed micelles (0.375/0.375/1 and 0.75/0.375/1) and Pluronic F127^®/Soluplus^®@VES-GEM mixed micelles (0.375/0.375/1 and 0.75/0.375/1) were prepared as explained above, but with co-dissolving polymeric surfactants at the desired concentration in the ethanolic VES-GEM solution, and stirred for 3 h at RT before dropwise addition to PBS diluted in water (50:50 v/v, 15 mL) [66 (link)].

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Pereira-Silva M., Miranda-Pastoriza D., Diaz-Gomez L., Sotelo E., Paiva-Santos A.C., Veiga F., Concheiro A, & Alvarez-Lorenzo C. (2024). Gemcitabine-Vitamin E Prodrug-Loaded Micelles for Pancreatic Cancer Therapy. Pharmaceutics, 16(1), 95.

Publication 2024

Corresponding Organization : Universidade de Santiago de Compostela

Other organizations : University of Coimbra, Rede de Química e Tecnologia, Center for Research in Molecular Medicine and Chronic Diseases

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Variable analysis

independent variables

Pluronic® F68 molar ratio
Pluronic® F127 molar ratio
Soluplus® molar ratio

dependent variables

Mixed micelle formation

control variables

VES-GEM concentration (1)
Ethanol solvent
Stirring time (3 h)
Room temperature
Dilution in PBS (50:50 v/v, 15 mL)

controls

No positive or negative controls were explicitly mentioned.

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