Chromogranin A and Synaptophysin Expression in Colorectal Cancer

We downloaded a total of 568 CRC and 44 normal tissues from TCGA (https://portal.gdc.cancer.gov). The data included RNA-seq profiles and clinicopathological information. We further compared the expression of CgA and SYP between normal and malignant samples. The overall survival and progression-free survival of patients expressing high and low levels of the two markers were also acquired by applying the Kaplan–Meier method (“limma,” “survival,” and “survminer” packages in R software).

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Chen Y., Liang Y., Cao L., Dong X, & Sun D. (2023). Neuroendocrine differentiation: a risk fellow in colorectal cancer. World Journal of Surgical Oncology, 21, 89.

Publication 2023

Cancer Normal tissues Patients Rna seq

Corresponding Organization : China Medical University

Top 5 similar protocols

Variable analysis

independent variables

RNA-seq profiles

dependent variables

Expression of CgA and SYP
Overall survival
Progression-free survival

control variables

Normal and malignant samples

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