Comparative Analysis of BRCA2 Protein Sequences

To evaluate the conserved regions, canine BRCA2 (accession No.: NP_001006654.2), human BRCA2 (accession No.: NP_000050.3), feline BRCA2 (accession No.:NP_001009858.1), mouse BRCA2 (accession No.:NP_001074470.1), chicken BRCA2 (accession No.: NP_989607.3), sea turtle BRCA2 (accession No.: XP_037747982.1), frog BRCA2 (accession No.: ABP48763.1), gecko BRCA2 (accession No.: XP_015279682.1), and zebrafish BRCA2 (Accession No.: NP_001103864.2) amino acid sequences were obtained from the NCBI database (https://www.ncbi.nlm.nih.gov (accessed on 19 October 2021)). Multi-species alignments were performed using the multiple sequence alignment program Clustal Omega (https://www.ebi.ac.uk/Tools/msa/clustalo/ (accessed on 19 October 2021)) according to the instruction manual (www.clustal.org/download/clustalw_help.txt, www.clustal.org/download/clustalx_help.html (accessed on 19 October 2021)) and using default settings [25 (link)], and then visualized using ESPript (http://espript.ibcp.fr/ (accessed on 28 December 2022)) [26 (link)].

Free full text: Click here

Zhu Z., Kitano T., Morimatsu M., Ochiai K., Ishiguro-Oonuma T., Oosumi K., Lin X., Orino K, & Yoshikawa Y. (2023). A Highly Conserved Region in BRCA2 Suppresses the RAD51-Interaction Activity of BRC Repeats. Veterinary Sciences, 10(2), 145.

Publication 2023

Amino acid sequences Brca2 Canine Chicken Feline Frog Gecko Human Mouse Sea turtle Sequence alignment Zebrafish

Corresponding Organization : Kitasato University

Other organizations : Hokkaido University, Nippon Veterinary and Life Science University, Iwate University

Top 5 similar protocols

Variable analysis

independent variables

Amino acid sequences of canine BRCA2 (accession No.: NP_001006654.2), human BRCA2 (accession No.: NP_000050.3), feline BRCA2 (accession No.:NP_001009858.1), mouse BRCA2 (accession No.:NP_001074470.1), chicken BRCA2 (accession No.: NP_989607.3), sea turtle BRCA2 (accession No.: XP_037747982.1), frog BRCA2 (accession No.: ABP48763.1), gecko BRCA2 (accession No.: XP_015279682.1), and zebrafish BRCA2 (Accession No.: NP_001103864.2)

dependent variables

Conserved regions in the BRCA2 amino acid sequences across different species

control variables

The multiple sequence alignment program Clustal Omega was used with default settings to align the BRCA2 amino acid sequences

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!