Patients over 18 years of age, presenting with lymph nodes suspected of malignancy in the neck and axilla on US, were evaluated prospectively. In B-mode US, long axis/short axis ratio >2 in the lymph node, >1 cm in the short axis, increased cortex thickness (>2.5 mm), absence of fatty hilus were regarded as a suspicion of malignancy(4 (link), 5 (link), 6 (link)). The lymph nodes which were suspicious for malignancy were followed-up for 12 weeks with an appropriate antibiotic therapy. During antibiotic treatment, 875 mg of amoxicillin and 125 mg of clavulanic acid were administered to the patients for 10 days. Subsequently, the reduction in size was monitored, and the lymph nodes suspected of malignancy were re-evaluated 12 weeks later.
The study was conducted prospectively between 2019 and 2020. Patients who did not agree to participate in the study, patients under the age of 18, patients with biopsy contraindications/refusal to biopsy, patients in whom US/biopsy could not be performed, and pregnant or lactating patients were excluded from the study. A total of 10 patients whose biopsy results were unsatisfactory and who met the exclusion criteria were excluded from the study.
Oral and written consents were obtained from the parents of all patients who participated in our study, as necessary. Ethical approval was obtained from the local scientific research ethics committee (decision No. 05, dated 17.01.2019). The study was conducted on the basis of ethical standards outlined in the Declaration of Helsinki of the World Medical Association. All sonographic evaluations were performed by two radiologists who are specialized in this field of radiology.