Mouse Models for Muscular Dystrophy Research

C57BL/10 (#:000476), mdx mice (C57BL/10ScSn-Dmdmdx/J) (#:001801) and mdx mice in the DBA2/J background (D2-mdx) (#:013141) were obtained from The Jackson Laboratory. CD45.1 congenic mice (#:002014) were also obtained from The Jackson Laboratory and crossed with mdx mice at the University of California Irvine (UCI). B6A/J (#:012767) and C57BL/6 mice (#:000664) were bred in vivariums at Children’s National Hospital. VCP (53 (link)) and DUX4 (54 ) mice were provided by collaborators at UCI and Ohio State University, respectively. Animal experiments were approved by the Institutional Animal Care and Use Committee of UCI.

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Coulis G., Jaime D., Guerrero-Juarez C., Kastenschmidt J.M., Farahat P.K., Nguyen Q., Pervolarakis N., McLinden K., Thurlow L., Movahedi S., Duarte J., Sorn A., Montoya E., Mozaffar I., Dragan M., Othy S., Joshi T., Hans C.P., Kimonis V., MacLean A.L., Nie Q., Wallace L.M., Harper S.Q., Mozaffar T., Hogarth M.W., Bhattacharya S., Jaiswal J.K., Golann D.R., Su Q., Kessenbrock K., Stec M., Spencer M.J., Zamudio J.R, & Villalta S.A. (2023). Single-cell and spatial transcriptomics identify a macrophage population associated with skeletal muscle fibrosis. bioRxiv.

Publication Preprint 2023

C57BL/10 C57BL/10ScSn-Dmdmdx/J) D2-mdx CD45.1 congenic mice

C57bl mice Congenic mice Dba2 Dux4 Institutional animal care and use committee Mdx mice Mice

Corresponding Organization : University of California, Irvine

Other organizations : Illinois College, University of Illinois Urbana-Champaign, University of California, Los Angeles, University of Missouri, Southern California University for Professional Studies, University of Southern California, The Ohio State University, Nationwide Children's Hospital, Regeneron (United States)

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Variable analysis

independent variables

Mouse strains: C57BL/10, mdx mice (C57BL/10ScSn-Dmdmdx/J), D2-mdx mice, CD45.1 congenic mice, B6A/J, C57BL/6, VCP mice, DUX4 mice

dependent variables

No dependent variables explicitly mentioned

control variables

Mouse strains were obtained from The Jackson Laboratory and bred in vivariums at Children's National Hospital
Animal experiments were approved by the Institutional Animal Care and Use Committee of UCI

positive controls

No positive controls explicitly mentioned

negative controls

No negative controls explicitly mentioned

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