Preterm labor was diagnosed by the presence of at least two regular uterine contractions every 10 min associated with cervical changes in patients with a gestational age between 20 and 36 6/7 weeks. Acute histologic chorioamnionitis was diagnosed according to previously described criteria [148 (link),149 (link)]. Funisitis was diagnosed when neutrophil infiltration was detected into the umbilical vessel walls or Wharton’s jelly using previously reported criteria [150–152 (link)]. Intra-amniotic inflammation was diagnosed when the AF IL-6 concentration was ≥2600 pg/ml (≥2.6 ng/ml), as determined by ELISA [46 (link),87 (link),117 (link),153 (link)]. MIAC was defined according to the results of AF culture. Intra-amniotic infection was defined as a combination of MIAC with intra-amniotic inflammation.
Protocol detail
Diagnosis of Preterm Labor and Intra-Amniotic Conditions
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Amniotic
Cervical
Chorioamnionitis
Elisa
Funisitis
Gestational age
Infection
Inflammation
Neutrophil infiltration
Patients
Preterm labor
Umbilical
Uterine contractions
Vessel
Wharton jelly
Corresponding Organization : Michigan State University
Other organizations : Wayne State University, Seoul National University
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Variable analysis
independent variables
- Gestational age between 20 and 36 6/7 weeks
- Presence of at least two regular uterine contractions every 10 minutes
- Cervical changes
- Preterm labor diagnosis
- Acute histologic chorioamnionitis diagnosis
- Funisitis diagnosis
- Intra-amniotic inflammation diagnosis
- Microbial invasion of the amniotic cavity (MIAC) diagnosis
- Intra-amniotic infection diagnosis
- Previously described criteria for acute histologic chorioamnionitis diagnosis [148, 149]
- Previously reported criteria for funisitis diagnosis [150–152]
- AF IL-6 concentration ≥2600 pg/ml (≥2.6 ng/ml) for intra-amniotic inflammation diagnosis [46, 87, 117, 153]
- AF culture results for MIAC diagnosis
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