48 h after the last morphine injection, the rimonabant treatment phase begun. Mice received an i.p. injection of Vehicle (Sal- or Mor-Veh), 1 mg/kg rimonabant (Sal- or Mor-Rim1) or 10 mg/kg (Sal- or Mor-Rim10) for eight consecutive days (Days 20–28). Animals were exposed to a 10-min open-field session 30 min after the injection. Locomotor activity was not measured during this phase.
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