Diverse Bioactive Compound Synthesis

One flavone ZN-006 [2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid], one benzofuran ZN-013 [(4-methoxybenzofuran-2-yl)(phenyl)methanone], and four quinolines VB-030 [2-(pyridin-4-yl)-4-(p-tolyl)quinoline], VB-031 [(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one], VB-037 [(E)-4-(3-(2-(5-nitroquinolin-2-yl)vinyl)quinolin-2-yl)morpholine] and VB-041 [2-(pyridin-4-yl)-N-(3-(N-(3,4,5,6-tetrahydro-2H-azepin-7-yl)sulfamoyl)phenyl)quinoline-4-carboxamide] were purchased from Enamine (Kyiv, Ukraine). Procedures for producing coumarins ZN-014 (ethyl 5-hydroxy-2-oxo- 2H-chromene-3-carboxylate) and ZN-015 [(E)-4-hydroxy-3-(3-(2-hydroxyphenyl)acryloyl)-2H-chromen-2-one] were as stated [28 (link)]. Congo red, kaempferol and 7,8-DHF, controls for cellular and/or biochemical assays were obtained from Sigma-Aldrich (St. Louis, MO, USA). In addition, LM-031 (3-benzoyl-5-hydroxychromen-2-one), a control for evaluating TRKB signaling, was synthesized as stated [30 (link)].

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Weng Z.K., Lin T.H., Chang K.H., Chiu Y.J., Lin C.H., Tseng P.H., Sun Y.C., Lin W., Lee-Chen G.J, & Chen C.M. (2023). Using ΔK280 TauRD Folding Reporter Cells to Screen TRKB Agonists as Alzheimer’s Disease Treatment Strategy. Biomolecules, 13(2), 219.

Publication 2023

VB-037 Congo red kaempferol 7,8-DHF

2h chromen 2 one Acetic acid Assays Benzofuran Cellular Coumarins Ethyl 2 oxo 2h chromene 3 carboxylate Flavone Imidazol Kaempferol Morpholine Quinoline Quinoline 4 carboxamide Quinolines Trkb Vinyl

Corresponding Organization : Chang Gung Memorial Hospital

Top 5 similar protocols

Variable analysis

independent variables

ZN-006 [2-((5-hydroxy-4-oxo-2-phenyl-4H-chromen-7-yl)oxy)acetic acid]
ZN-013 [(4-methoxybenzofuran-2-yl)(phenyl)methanone]
VB-030 [2-(pyridin-4-yl)-4-(p-tolyl)quinoline]
VB-031 [(E)-3-(3-(1H-benzo[d]imidazol-2-yl)acryloyl)-6-methyl-4-phenylquinolin-2(1H)-one]
VB-037 [(E)-4-(3-(2-(5-nitroquinolin-2-yl)vinyl)quinolin-2-yl)morpholine]
VB-041 [2-(pyridin-4-yl)-N-(3-(N-(3,4,5,6-tetrahydro-2H-azepin-7-yl)sulfamoyl)phenyl)quinoline-4-carboxamide]
ZN-014 (ethyl 5-hydroxy-2-oxo- 2H-chromene-3-carboxylate)
ZN-015 [(E)-4-hydroxy-3-(3-(2-hydroxyphenyl)acryloyl)-2H-chromen-2-one]

dependent variables

Outcomes measured in cellular and/or biochemical assays

control variables

Congo red
Kaempferol
7,8-DHF
LM-031 (3-benzoyl-5-hydroxychromen-2-one)

Annotations

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