VX2 Lung Tumor PET Imaging Protocol

Two weeks after VX2 inoculation, the lung tumors had reached a size of almost 30–40 mm, and were thus suitable for preclinical research [22 (link)]. To assess tumor formation in each group, 12 randomly selected rabbits (3 per group) underwent 18F-fluorodeoxyglucose positron emission tomography (¹⁸FDG-PET) using a Gemini TF 16-slice PET scanner (Philips Medical Systems, Cleveland, OH, USA). All rabbits were fasted for at least 12 hours before scanning and were anesthetized with tiletamine-zolazepam and xylazine as described above. Each rabbit received approximately 37 MBq (1 mCi) ¹⁸FDG through the auricular vein, and chest PET images were acquired over 60 min. PET images were displayed and analyzed at a dedicated workstation (Extended Brilliance Workspace 3.5; Philips Medical Systems).

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Choi B.H., Young H.S., Quan Y.H., Rho J., Eo J.S., Han K.N., Choi Y.H, & Hyun Koo K. (2017). Real-time computed tomography fluoroscopy-guided solitary lung tumor model in a rabbit. PLoS ONE, 12(6), e0179220.

Publication 2017

Extended Brilliance Workspace 3.5

18fdg Chest Inoculation Lung tumors Positron emission tomography Rabbit Rabbits Tiletamine zolazepam Tumor Vein Xylazine

Corresponding Organization : Korea University Medical Center

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Variable analysis

independent variables

VX2 inoculation

dependent variables

Lung tumor size
Tumor formation (assessed by 18F-fluorodeoxyglucose positron emission tomography, 18FDG-PET)

control variables

Fasting duration (at least 12 hours before scanning)
Anesthesia (tiletamine-zolazepam and xylazine)
Dose of 18FDG (approximately 37 MBq, 1 mCi)
Scanning duration (60 minutes)

controls

No positive or negative controls were explicitly mentioned.

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