Antibiotic Resistance Profile of N. gonorrhoeae

The resistance profile of the confirmed N. gonorrhoea for seven antibiotics (Mast Group Ltd, UK) – penicillin (PG: 10 units), azithromycin (ATH: 15 µg), ceftriaxone (CRO: 30 µg), ciprofloxacin (CIP: 5 µg), erythromycin (E: 15 µg), togamycin (TG: 10 µg) and tetracycline (T: 30 µg) – was evaluated using the disc diffusion method following the procedure and guidelines of the Clinical and Laboratory Standards Institute (CLSI) [21 ]. For azithromycin, the Centers for Disease Control and Prevention (CDC’s) breakpoint was used to interpret its results. Triplicate averages of the inhibition zones were used for this purpose. The ratio of antibiotics resisted by an isolate to the number of antibiotics tested on the isolate, multiplied by 100%, was used to indicate an antibiotic’s antimicrobial resistance percentage. Multiple AMR index was evaluated as a ratio of the number of antibiotics an isolate is resistant to the number of antibiotics evaluated on the isolate as previously described [19 (link)].

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Musah H.S., Addy F, & Dufailu O.A. (2024). Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoea isolates in Ghana. Access Microbiology, 6(2), 000689.v3.

Publication 2024

penicillin azithromycin

Corresponding Organization :

Other organizations : University for Development Studies, University of Greenwich

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Variable analysis

independent variables

Penicillin (PG: 10 units)
Azithromycin (ATH: 15 µg)
Ceftriaxone (CRO: 30 µg)
Ciprofloxacin (CIP: 5 µg)
Erythromycin (E: 15 µg)
Togamycin (TG: 10 µg)
Tetracycline (T: 30 µg)

dependent variables

Resistance profile of confirmed N. gonorrhoea

control variables

Disc diffusion method following the procedure and guidelines of the Clinical and Laboratory Standards Institute (CLSI)
Use of the Centers for Disease Control and Prevention (CDC's) breakpoint to interpret azithromycin results

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