Measuring GFR in Korean CKD Patients

We recruited CKD patients (n=120) in outpatient department and healthy volunteers (n=31) from Seoul National University Hospital for the clinical study, 'Measurement of glomerular filtration rate and calculation of GFR estimates for Korean' granted by the Korean Society of Nephrology from April 2008 to February 2009. All of volunteers showed normal urinalysis and their systemic inulin clearances were greater than 60 mL/min/1.73 m² (66.4-151.3 mL/min/1.73 m²). Inclusion criteria were as follows: 1) participants who agreed with the study and voluntarily signed on informed consent, 2) aged 18 yr or older. Exclusion criteria of this study were as follows: 1) rapid decline of renal function within 3 months, 2) edema or ascites, 3) proteinuria greater than 10 g/day or serum albumin less than 2.5 g/dL, 4) active infection, 5) coronary artery intervention i.e., coronary artery bypass graft (CABG) or percutaneous coronary intervention (PCI) within 1 yr (except stabilization after unstable angina or heart failure), 6) liver enzyme abnormality (serum AST/ALT greater than 2×upper normal range), 7) history of severe allergy like angioedema, 8) pregnant or lactating women, 9) gross hematuria, 10) oliguria less than 500 mL/day), 11) renal replacement therapy. This study was approved by the Institutional Review Board of Seoul National University Hospital (IRB No. 0701-006-193).