Structural Analysis of Ape PHACTR2 Protein

The predictions of the domains, repeats, motifs, and features within Ape’s (Pongo abellii) PHACTR2 protein isoform 4 were retrieved from the SMART database (simple modular architecture research tool, http://smart.embl-heidelberg.de/, accessed on 20 February 2018). The 3D structure modeling of the PHACTR2 protein was created using the Swiss model server. The amino acid sequence of human PHACTR2 was retrieved from the NCBI protein database (NP_055536.2). Since the residues around the variation site were conserved, we used the crystal structure of mouse PHACTR1 with actin (PDB structure 4B1Z) for the structural analysis. Color modifications on the protein were changed using PyMOL software.