Characterization of Lipid-Based Nanoparticles

The TL formulations were diluted in distilled water and used as samples for measurement. The size dispersion of the TL-MPs-Gel was analyzed on a SALD-7100 (Shimadzu Corp., Kyoto, Japan) with the refractive index set at 1.60-0.10i. In addition, the size distribution and number of nanoparticles in the TL-NPs-Gel were measured using a NANOSIGHT LM10 (QuantumDesign Japan, Tokyo, Japan) with the viscosity, wavelength and measurement time set to 1.27 mPa⋅s, 405 nm and 60 s, respectively. Atomic force microscopic (AFM) images were provided by a SPM-9700 (Shimadzu Corp., Kyoto, Japan) according to previous report [33 (link)].

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Minami M., Seiriki R., Otake H., Nakazawa Y., Kanai K., Tanino T, & Nagai N. (2020). Development of Sustained-Release Ophthalmic Formulation Based on Tranilast Solid Nanoparticles. Materials, 13(7), 1675.

Publication 2020

SALD-7100 NANOSIGHT LM10 SPM-9700

Atomic force microscopic Lm10 Viscosity

Corresponding Organization : Kindai University

Other organizations : Keio University, Kitasato University, Tokushima Bunri University

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Variable analysis

independent variables

Dilution of TL formulations in distilled water

dependent variables

Size dispersion of TL-MPs-Gel
Size distribution and number of nanoparticles in TL-NPs-Gel

control variables

Refractive index set at 1.60-0.10i for SALD-7100 analysis
Viscosity set at 1.27 mPa⋅s, wavelength at 405 nm, and measurement time at 60 s for NANOSIGHT LM10 analysis

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