Tissue Distribution of Anti-Liver Cancer Drug

Tissue distribution studies in mice with SCID are required in anti-liver cancer activity to determine the distribution and concentration of a drug within the body after administration (54 (link)). This information is important for understanding how the drug is metabolized and cleared by the body, as well as for determining appropriate dosing regimens. Additionally, tissue distribution studies can help to identify any potential toxicities or side effects associated with the drug in specific organs or tissues. In the case of anti-liver cancer activity, knowing the distribution of the drug in the liver would be particularly important to ensure the drug is reaching its target site and effectively inhibiting the growth of cancer cells. The tissue distribution of a bolus dosage of 20 mg/kg i.v. Cabozantinib (CNB), CNB-PLGA-PSar-NPs was documented. The greatest concentration of CNB was found in liver parenchymal hepatocyte tissue. The presence of CNB in the tissues of other essential organs, such as the heart and kidney, suggests that CNB distribution is indirectly dependent on the blood flow and perfusion rate of the organs. The increased affinity of CNB in the liver and pancreas enables the medication molecule to effectively treat liver cancer. However, limited expression of CNB in brain endothelial cells suggests that polymeric nanoparticles are unable to traverse the blood-brain barrier without difficulty.

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Bhattacharya S., Parihar V.K, & Prajapati B.G. (2023). Unveiling the therapeutic potential of cabozantinib-loaded poly D,L-lactic-co-glycolic acid and polysarcosine nanoparticles in inducing apoptosis and cytotoxicity in human HepG2 hepatocellular carcinoma cell lines and in vivo anti-tumor activity in SCID female mice. Frontiers in Oncology, 13, 1125857.

Publication 2023

Blood brain barrier Blood flow Body Brain Cabozantinib Cancer Drug distribution Endothelial cells Heart Hepatocyte Kidney Liver Liver cancer Medication Mice Pancreas Parenchymal tissue Perfusion Plga Polymeric Regimens Scid Tissues

Corresponding Organization :

Other organizations : Narsee Monjee Institute of Management Studies, National Institute of Pharmaceutical Education and Research, Ganpat University

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Variable analysis

independent variables

Dose of Cabozantinib (CNB)
Formulation (CNB-PLGA-PSar-NPs)

dependent variables

Tissue distribution of Cabozantinib (CNB)
Concentration of Cabozantinib (CNB) in various tissues

control variables

Administration route (intravenous, i.v.)
Dosage (20 mg/kg)

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