NLRP3 Inflammasome Activation Regulation
Corresponding Organization :
Other organizations : Zhejiang Chinese Medical University, Guangdong Pharmaceutical University, Tongde Hospital of Zhejiang Province, Hangzhou Normal University, Hangzhou First People's Hospital, Zhejiang University
Variable analysis
- Honokiol
- MCC950 (ASC oligomerization inhibitor)
- VX-765 (Caspase-1 inhibitor)
- IL-33
- NLRP3 oligomerization
- Caspase-1 activation
- IL-1β release
- Renal function (Blood Urea Nitrogen, Creatinine)
- Cell culture conditions (RPMI-1640 media, FBS)
- Transfection reagents (p3*flag-NLRP3, P3 Primary Cell 4D-Nucleofector X Kit L)
- Protein quantification (Bradford Assay kit, BCA Protein Assay kit)
- Western blot (PVDF membranes, secondary antibodies)
- ELISA kits (Mouse IL-33, Mouse IL-1β, Rat IL-1β, Rat IL-18)
- Recombinant NLRP3 protein
- Vehicle controls for each treatment
Annotations
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