Ga-PSMA-11 PET/MRI and PET/CT for Prostate Cancer Staging

Sixty minutes after [⁶⁸Ga]PSMA-11 administration, 58/73 patients underwent PET/MRI (SIGNA PET/3.0 T MRI, GE Healthcare) and 15/73 PET/CT (Discovery VCT 690 or Discovery MI PET/CT, GE Healthcare) scans for staging PCa with an administered [⁶⁸Ga]PSMA-11 dose of 2 MBq/kg (mean activity 132.9 ± 19.1 MBq, range 94–177). Scans were performed with the same protocol for prostate imaging as recently described [15 (link)]. To reduce the radiopharmaceutical activity in the urinary system, furosemide was injected intravenously 30 min before the tracer injection (0.13 mg/kg), and patients were asked to void before the scan. The institutional protocol was in agreement with the joint EANM-SNMMI procedure guidelines [16 (link)].

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Laudicella R., Skawran S., Ferraro D.A., Mühlematter U.J., Maurer A., Grünig H., Rüschoff H.J., Rupp N., Donati O., Eberli D, & Burger I.A. (2022). Quantitative imaging parameters to predict the local staging of prostate cancer in intermediate- to high-risk patients. Insights into Imaging, 13, 75.

Publication 2022

Discovery VCT 690 Discovery MI

Furosemide Joint Patients Pet ct Prostate Radiopharmaceutical Scan Void

Corresponding Organization : Kantonsspital Baden

Other organizations : University Hospital of Zurich, University of Zurich

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Variable analysis

independent variables

Administered [^68^Ga]PSMA-11 dose (2 MBq/kg)

dependent variables

PET/MRI scans for staging PCa
PET/CT scans for staging PCa

control variables

Furosemide injection (0.13 mg/kg) 30 min before the tracer injection to reduce radiopharmaceutical activity in the urinary system
Patients were asked to void before the scan
Scanning protocol for prostate imaging as recently described [15]
Institutional protocol in agreement with the joint EANM-SNMMI procedure guidelines [16]

controls

Positive control: Not explicitly mentioned.
Negative control: Not explicitly mentioned.

Annotations

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