Volunteers who meet the following conditions can be included in the trial: 1) healthy men and women aged 18–45, with a body mass index of 19-28 kg / m2 (including the boundary value). The weight of male is not less than 50.0 kg, and that of female is not less than 45.0 kg. 2) Good health, no history of cardiovascular system, digestive system, urinary system, endocrine system, blood system, respiratory system, nervous system, etc. The following examination results are normal or abnormal with no clinical significance. The examinations include: body temperature, blood pressure, heart rate, hematology, blood biochemistry, urinalysis, serological detection of hepatitis B virus, hepatitis C virus, human immunodeficiency virus (HIV) and Treponema pallidum, coagulation, 12 lead electrocardiogram (ECG), alcohol breath test, drug screening and female pregnancy test. 3) The subjects and their spouses did not have family planning within 6 months and chose appropriate contraceptive methods. 4) Before the study, all subjects were informed of the purpose, process, benefits and risks of the study and voluntarily signed informed consent.
Subjects who were allergic to study drugs, smoke, drink alcohol, and participate in other clinical trials within 3 months could not participate in the trial.
Free full text: Click here