Evaluating the Efficacy of DNA-PK and KIT Inhibitors

Cell lines were treated with the following agents, either alone or in combination as indicated in text. DNA-PK inhibitors: NU7441 (Selleckchem), M3814 (Merck); KIT signaling inhibitors: dasatinib (Cayman Chemical), ibrutinib (Selleckchem), FTY720 (Cayman Chemical), and AAL(S) (synthesized by A/Prof Jonathan Morris, School of Chemistry, UNSW as described (43 (link))). Dimethyl sulfoxide was used as the solvent for all compounds. Final vehicle concentration was below 0.1% for all experiments.

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Murray H.C., Miller K., Brzozowski J.S., Kahl R.G., Smith N.D., Humphrey S.J., Dun M.D, & Verrills N.M. (2023). Synergistic Targeting of DNA-PK and KIT Signaling Pathways in KIT Mutant Acute Myeloid Leukemia. Molecular & Cellular Proteomics : MCP, 22(3), 100503.

Publication 2023

NU7441 M3814 dasatinib ibrutinib FTY720

Cayman Cell lines Dasatinib Dimethyl sulfoxide Dna pk Fty720 Ibrutinib Inhibitors M3814 Nu7441 Solvent

Corresponding Organization :

Other organizations : Hunter Medical Research Institute, University of Newcastle Australia, University of Sydney

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Variable analysis

independent variables

NU7441 (Selleckchem)
M3814 (Merck)
Dasatinib (Cayman Chemical)
Ibrutinib (Selleckchem)
FTY720 (Cayman Chemical)
AAL(S) (synthesized by A/Prof Jonathan Morris, School of Chemistry, UNSW as described (43 (link)))

dependent variables

Measured outcomes

control variables

Dimethyl sulfoxide (used as the solvent for all compounds)
Final vehicle concentration below 0.1% for all experiments

controls

Positive controls
Negative controls

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