Antimicrobial Potency Assessment of SQQ30 and TRS21

The minimal inhibitory concentrations (MICs) of SQQ30 peptide and TRS21 against the strains were determined according to Heydari, M., et al., 2018 [47 (link)]; 5 × 10⁵ CFU/mL of each bacteria strain was added to 95 µL of Mueller–Hinton broth (CAM-HB; Fisher scientific, Segrate, Italy) that was supplemented or not with SQQ30 (0.1–50 µM) and TRS21 (0.5–200 µM).
The positive control was represented by gentamicin for all bacterial strains.

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Di Napoli M., Castagliuolo G., Pio S., Di Nardo I., Russo T., Antonini D., Notomista E., Varcamonti M, & Zanfardino A. (2024). Study of the Antimicrobial Activity of the Human Peptide SQQ30 against Pathogenic Bacteria. Antibiotics, 13(2), 145.

Publication 2024

CAM-HB

Corresponding Organization : University of Naples Federico II

Other organizations : Institute of Polymers, Composites and Biomaterials, National Research Council

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Variable analysis

independent variables

SQQ30 peptide (concentration range: 0.1-50 µM)
TRS21 (concentration range: 0.5-200 µM)

dependent variables

Minimal inhibitory concentrations (MICs) of SQQ30 peptide and TRS21 against the bacterial strains

control variables

Initial bacterial inoculum: 5 × 10^5 CFU/mL
Culture medium: Mueller-Hinton broth (CAM-HB)

controls

Positive control: Gentamicin for all bacterial strains

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