Synthesis and Characterization of PI-103 Compound

RIDR-PI-103 was synthesized as described [29 (link)]. PI-103 (Cat# S1038) was obtained from Selleckchem (Houston, Texas, USA). All drugs were dissolved in dimethyl sulfoxide (DMSO) (Fisher Scientific, Waltham, Massachusetts, USA) at desired concentrations and stored at −20°C. Glutathione was obtained from Fisher Scientific (Cat# BP25211). N-acetyl cysteine (NAC) was obtained from Fisher Scientific (Cat# AAA1540936). TBHP was obtained from Fisher Scientific (Cat# AC180340050). Dabrafenib (Cat# D-5699) and trametinib (Cat# T-8123) were purchased from LC Laboratories (Woburn, Massachusetts, USA).

Partial Protocol Preview
This section provides a glimpse into the protocol.
The remaining content is hidden due to licensing restrictions, but the full text is available at the following link: Access Free Full Text.

Patel H., Mishra R., Wier A., Mokhtarpour N., Merino E.J, & Garrett J.T. (2023). RIDR-PI-103, ROS-activated prodrug PI3K inhibitor inhibits cell growth and impairs the PI3K/Akt pathway in BRAF and MEK inhibitor-resistant BRAF-mutant melanoma cells. Anti-Cancer Drugs, 34(4), 519-531.

Publication 2023

PI-103 Glutathione Dabrafenib trametinib

Dabrafenib Dimethyl sulfoxide Drugs Glutathione N acetyl cysteine Pi 103 Trametinib

Corresponding Organization : University of Cincinnati Medical Center

Other organizations : Hillsdale College, University of Cincinnati

Top 5 similar protocols

Variable analysis

independent variables

RIDR-PI-103 (synthesized as described in [29])
PI-103 (obtained from Selleckchem)
Glutathione (obtained from Fisher Scientific)
N-acetyl cysteine (NAC) (obtained from Fisher Scientific)
TBHP (obtained from Fisher Scientific)
Dabrafenib (obtained from LC Laboratories)
Trametinib (obtained from LC Laboratories)

dependent variables

Not explicitly mentioned

control variables

All drugs were dissolved in dimethyl sulfoxide (DMSO) (Fisher Scientific) at desired concentrations and stored at −20°C.

controls

Positive control: Not specified
Negative control: Not specified

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!