Systematic Review of PD1/PD-L1 and Anti-Angiogenic Therapy
The inclusion criteria were as follows: retrospective studies and prospective studies (including single-arm studies, cohort studies, and randomized control trials); patients who were pathologically diagnosed with any type of solid cancer; patients treated with PD1/PD-L1 inhibitors combined with anti-angiogenic drugs and RT; and studies that reported efficacy endpoints, including objective response rate (ORR), complete response rate (CRR), disease control rate (DCR), mortality rate (MR), and AEs. The exclusion criteria were as follows: experiments performed in vitro or in vivo, but not based on patients; incomplete data for the targeted outcomes; patients with hematologic tumors, including leukemia, multiple myeloma, and malignant lymphoma; and studies published as conference abstracts, reviews, comments, case reports, and letters. Two researchers independently reviewed the titles and abstracts of the studies and submitted eligible studies for full-text analysis to confirm whether they should be included in the meta-analysis. After each selection stage, the 2 researchers compared their findings. Inconsistencies were resolved and discussed by a third researcher.
Xian F., Wu J., Zhong L, & Xu G. (2023). Efficacy and safety of PD1/PDL1 inhibitors combined with radiotherapy and anti-angiogenic therapy for solid tumors: A systematic review and meta-analysis. Medicine, 102(10), e33204.
PD1/PD-L1 inhibitors combined with anti-angiogenic drugs and RT
dependent variables
Objective response rate (ORR)
Complete response rate (CRR)
Disease control rate (DCR)
Mortality rate (MR)
control variables
Patients who were pathologically diagnosed with any type of solid cancer
Annotations
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