Fourier transform infrared spectroscopic analysis (FTIR) FTIR analysis was conducted to investigate the compatibility of DTX with Soluplus ® and PF108. FTIR spectra were recorded for plain DTX, Soluplus ® , PF108, and a physical mixture of DTX, Soluplus ® , and PF108. Samples for FTIR were prepared following a methodology based on the principles outlined by Patravale et al. This involved maintaining a specific 1:0.5 ratio of active pharmaceutical ingredient (API) to solubilizers, mainly Soluplus ® and PF108. Each unit of the API was combined with 0.5 units of Soluplus ® and PF108. The FTIR measurements were performed using an Agilent Alpha 100508 instrument over a wave number range of 4000 to 400 cm -1 [27] .
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FTIR Analysis of DTX-Soluplus-PF108 Compatibility
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Other organizations : Shivaji University, Dr. Babasaheb Ambedkar Technological University
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Variable analysis
independent variables
- Ratio of active pharmaceutical ingredient (API) to solubilizers (Soluplus® and PF108)
- FTIR spectra
- Wave number range (4000 to 400 cm-1)
- FTIR instrument (Agilent Alpha 100508)
- Plain DTX (as a control)
- Soluplus® (as a control)
- PF108 (as a control)
- Physical mixture of DTX, Soluplus®, and PF108 (as a control)
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