Alcohol Cue-Reactivity Neuroimaging Protocol

Participants were scanned at the midpoint study visit (Day 8). Neuroimaging took place at the UCLA Center for Cognitive Neuroscience on a 3.0 T Siemens Prisma Scanner (Siemens Medical Solutions USA, Inc., Malvern, PA). Detailed neuroimaging procedures can be found in the Supplement. Participants completed a 720-s-long alcohol cue-reactivity task [40 (link)], in which they were presented with 24 pseudo-randomly interspersed blocks of alcoholic beverage images (ALC), non-alcoholic beverage images (BEV), blurred images to serve as visual controls, and a fixation cross. Each block was composed of five individual pictures of the same type, each presented for 4.8 s, for a total of 24 s. Each block was followed by a 6-s washout period during which participants reported on the urge to drink. Alcoholic beverage blocks were distributed between images of beer, wine, and liquor (two of each).

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Grodin E.N., Bujarski S., Towns B., Burnette E., Nieto S., Lim A., Lin J., Miotto K., Gillis A., Irwin M.R., Evans C, & Ray L.A. (2021). Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial. Translational Psychiatry, 11, 355.

Publication 2021

Siemens Prisma Scanner

Alcohol Alcoholic beverage Beer Liquor Prisma Supplement Wine

Corresponding Organization :

Other organizations : University of California, Los Angeles

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Variable analysis

independent variables

Type of image presented to participants (alcoholic beverage, non-alcoholic beverage, blurred, fixation cross)

dependent variables

Urge to drink reported by participants after each block

control variables

Presentation time of each image (4.8 s)
Number of images per block (5)
Duration of each block (24 s)
Duration of washout period between blocks (6 s)
Total duration of the task (720 s)
Magnetic field strength of the MRI scanner (3.0 T)
MRI scanner model (Siemens Prisma)

controls

Blurred images to serve as visual controls
Fixation cross to serve as a control condition

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