C. difficile Outbreak Investigation in Pediatric Oncology

The Center for Cancer and Blood Disorders (CCBD) Program, which includes inpatient and outpatient services for oncology, hematology, and bone marrow transplant patients, is located on a single floor of the free-standing Children’s Hospital of Colorado (CHCO). As previously described, as part of a C. difficile outbreak investigation, stool samples were collected from all patients admitted to the pediatric CCBD floor from October through December 2012.[9 (link), 21 (link)] Stool samples were tested for the C. difficile toxin B gene by PCR (Xpert C. difficile, Cepheid, Sunnyvale CA). An aliquot of stool was stored at -70°C and later thawed for sequence analysis. Clinical histories were ascertained by retrospective chart review. Research and data collection protocols were approved by the Colorado Multiple Institutional Review Board. Waiver of informed consent was approved for retrospective chart review of study participants.

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Nycz B.T., Dominguez S.R., Friedman D., Hilden J.M., Ir D., Robertson C.E, & Frank D.N. (2018). Evaluation of bloodstream infections, Clostridium difficile infections, and gut microbiota in pediatric oncology patients. PLoS ONE, 13(1), e0191232.

Publication 2018

Xpert C. difficile

Blood disorders Bone marrow transplant Cancer Cancer blood Children Inpatient Institutional review board Oncology Outpatient services Patients Sequence analysis Stool

Corresponding Organization : Center for Cancer and Blood Disorders

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

Detection of C. difficile toxin B gene by PCR in stool samples

control variables

Admission to the pediatric CCBD floor from October through December 2012
Retrospective chart review for clinical histories

controls

None explicitly mentioned

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