Synthesis of HIF Stabilizers

FG-4592 was from Selleck Chemicals. IOX-4 was synthesized according to the reported procedure.31 (link) GSK1278863, Vadadustat, and Molidustat were synthesized as described in the ESI.†

Free full text: Click here

Yeh T.L., Leissing T.M., Abboud M.I., Thinnes C.C., Atasoylu O., Holt-Martyn J.P., Zhang D., Tumber A., Lippl K., Lohans C.T., Leung I.K., Morcrette H., Clifton I.J., Claridge T.D., Kawamura A., Flashman E., Lu X., Ratcliffe P.J., Chowdhury R., Pugh C.W, & Schofield C.J. (2017). Molecular and cellular mechanisms of HIF prolyl hydroxylase inhibitors in clinical trials †Electronic supplementary information (ESI) available: Synthetic procedures; supplementary methods including NMR, OGFOD1/Tpa1a/OFD1/PHD2/FIH hydroxylation assays, cell culture and immunoblotting, RT-qPCR assays and cell viability assays; supplementary figures; supplementary tables. See DOI: 10.1039/c7sc02103h. Chemical Science, 8(11), 7651-7668.

Publication 2017

FG-4592

Fg 4592 Gsk1278863 Molidustat Vadadustat

Corresponding Organization : Oxfam

Other organizations : Ludwig Cancer Research, Wellcome Centre for Human Genetics, The Francis Crick Institute

Top 5 similar protocols

Variable analysis

independent variables

FG-4592 from Selleck Chemicals
IOX-4 synthesized according to the reported procedure
GSK1278863 synthesized as described in the ESI
Vadadustat synthesized as described in the ESI
Molidustat synthesized as described in the ESI

dependent variables

Measured outcomes (not explicitly mentioned)

control variables

Control variables not explicitly mentioned

controls

Positive control not mentioned
Negative control not mentioned

Annotations

Based on most similar protocols

Etiam vel ipsum. Morbi facilisis vestibulum nisl. Praesent cursus laoreet felis. Integer adipiscing pretium orci. Nulla facilisi. Quisque posuere bibendum purus. Nulla quam mauris, cursus eget, convallis ac, molestie non, enim. Aliquam congue. Quisque sagittis nonummy sapien. Proin molestie sem vitae urna. Maecenas lorem.

As authors may omit details in methods from publication, our AI will look for missing critical information across the 5 most similar protocols.

About PubCompare

Our mission is to provide scientists with the largest repository of trustworthy protocols and intelligent analytical tools, thereby offering them extensive information to design robust protocols aimed at minimizing the risk of failures.

We believe that the most crucial aspect is to grant scientists access to a wide range of reliable sources and new useful tools that surpass human capabilities.

However, we trust in allowing scientists to determine how to construct their own protocols based on this information, as they are the experts in their field.

Ready to get started?

Revolutionizing how scientists
search and build protocols!