Corticosterone (CORT, 235135) was purchased from sigma, nor-Binaltorphimine dihydrochloride (nor-BNI, ab120078) and anti-dynorphin A17 antibody (DYN A17, ab82509) were purchased from Abcam, Anti-oprk 1 antibody (A14035) was purchased from Wuhan ABclonal, magnolol (M111378) was purchased from aladdin, uoxetine (HY-B0102) was purchased from MCE. Magnolol (25/50/100 mg/kg/day), nor-BNI (10 mg/kg/day) and uoxetine (10 mg/kg/day) were uniformly dispersed in 1% Tween 80 and then dissolved in distilled water. All drugs were administered in an injection volume of 4 mL/ kg - 1 (i.p.). All drugs were dispensed on the spot [34] .
Protocol detail
Pharmacological Modulation of Dynorphin
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Corresponding Organization :
Other organizations : The Third Affiliated Hospital of Zhejiang Chinese Medical University, Zhejiang Chinese Medical University
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Variable analysis
independent variables
- Magnolol (25/50/100 mg/kg/day)
- Nor-BNI (10 mg/kg/day)
- Fluoxetine (10 mg/kg/day)
- Not explicitly mentioned
- Tween 80 (1%) dissolved in distilled water
- Injection volume of 4 mL/kg-1 (i.p.)
- None specified
- None specified
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