Naloxone and Magnesium Chloride Intramuscular/Subcutaneous Solution

Example 3

TABLE 3

ComponentQuantity per dose (mg)Concentration (mg/ml)

Naloxone or a55

pharmaceutically

acceptable

salt thereof

Magnesium Chloride1010

Aqueous solutions are prepared and hydrochloric acid is added to adjust pH to about 3.8 to 4.5. The solution is contained in a device suitable for intramuscular or subcutaneous administration.

The following examples set forth a study performed in dogs to assist in understanding the invention and should not be construed as specifically limiting the invention described and claimed herein. Such variations of the invention, including the substitution of any or all equivalents now known or later developed, which would be within the purview of those skilled in the art, and changes in formulation or minor changes in therapeutic design, are to be considered to fall within the scope of the invention incorporated herein.

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US11857547B2. Compositions and methods for opioid antagonist delivery (2024-01-02). Purdue Pharma L.P. [US]. Inventors: Haiyong Hugh Huang [US], Manjunath S. Shet [US].

Patent 2024

Delivery Device Dogs Hydrochloric acid Magnesium chloride Naloxone Opioid antagonist Salt Therapeutic

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Variable analysis

independent variables

None explicitly mentioned

dependent variables

None explicitly mentioned

control variables

PH of the aqueous solutions (adjusted to about 3.8 to 4.5 using hydrochloric acid)
Device used for intramuscular or subcutaneous administration

controls

No positive or negative controls are explicitly mentioned in the given text.

Annotations

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