Example 8
Cells were treated with troglitazone, followed by incubation with the various fluorescence dyes (CALCEIN AM, MBBR, MITOSOX™ and CYTOSOX™). For each non-control well, the quadratic chi-distance distance to positive and negative control templates (for each fluorescence channel) was calculated and normalized with the scaling factor. The normalized data are reorganized into tensors, and the distance from positive and negative control templates are calculated. The similarities of the trioglitazone tensor to another compound tensor can be computed using known techniques by comparing the fiber columns of the tensors using dynamic time warping distance (see, Giorgino et al. “Computing and Visualizing Dynamic Time Warping Alignments in R: The dtw Package.” Journal of Statistical Software, 31(7), 1-24, 2009). Dissimilarities or distances to all other compounds can be calculated this way.
Results are shown in
