Solubilization of Tranilast and Pirfenidone

Tranilast (Rizaben®, Kissei Pharmaceutical, Japan) was solubilized with 1% NaHCO₃ followed by heating at 70^°C for 1 h (33.3mg/ml) [17 (link),19 (link),20 (link)]. Pirfenidone (Esbriet®, Roche Pharmaceuticals, Switzerland) was solubilized with sterile water followed by warming at 60^°C for 30min [18 (link)]. We have previously showed that these drugs can reduce levels of hyaluronan and collagen type I in murine breast tumor models [17 (link),18 (link)].

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Voutouri C, & Stylianopoulos T. (2018). Accumulation of mechanical forces in tumors is related to hyaluronan content and tissue stiffness. PLoS ONE, 13(3), e0193801.

Publication 2018

Pirfenidone

Breast tumor Collagen type i Drugs Esbriet Hyaluronan Murine Nahco3 Pirfenidone Rizaben Sterile Tranilast

Corresponding Organization : University of Cyprus

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Variable analysis

independent variables

Solubilization of Tranilast (Rizaben®, Kissei Pharmaceutical, Japan) with 1% NaHCO3 followed by heating at 70°C for 1 h
Solubilization of Pirfenidone (Esbriet®, Roche Pharmaceuticals, Switzerland) with sterile water followed by warming at 60°C for 30min

dependent variables

Levels of hyaluronan and collagen type I in murine breast tumor models

control variables

Not explicitly mentioned

controls

Positive control: Not explicitly mentioned
Negative control: Not explicitly mentioned

Annotations

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