Age, sex, length of ICU stay, history of SLE, renal biopsy pathology, organ damage (including skin, serositis, arthritis, heart, kidney, blood, central nervous and other system damage) and type and dose of immunosuppressants in the 2 months before ICU admission were recorded. Laboratory indicators included CRP, TLC, CD3 + , CD4 + , CD8 + , CD20 + lymphocyte count, albumin, globulin, procalcitonin (PCT), interleukin-6 (IL-6), hemoglobin (Hgb), platelet (PLT), N-terminal B-type natriuretic peptide (NT-proBNP), serum creatinine (Scr), blood urea nitrogen (BUN), complement C3, complement C4, antinuclear antibody (ANA), anti–double-stranded DNA antibody (anti-dsDNA), anticardiolipin antibody (ACL), lupus anticoagulant factor (LA), and proteinuria. The SLE Disease Activity Index (SLE-DAI) and Acute Physiology and Chronic Health Assessment (APACHE) II scores were calculated. The diagnosis of pulmonary infection and severe pulmonary infection was based on diagnostic criteria developed by the Infectious Diseases Society of America/American Thoracic Society (IDSA/ATS) [11 (link)]. Sepsis was defined according to the diagnostic criteria Sepsis 3.0 [12 (link)]. ARDS was defined according to the Berlin diagnostic criteria [13 (link)].
Protocol detail
Predictors of Severe Outcomes in SLE-Associated ICU Admissions
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Albumin
Anti double stranded dna antibody
Anticardiolipin antibody
Antinuclear antibody
Ards
Arthritis
Biopsy
Blood
Blood urea nitrogen
Complement c3
Complement c4
Creatinine
Diagnostic
Dsdna
Globulin
Heart
Hemoglobin
Immunosuppressants
Infection
Infectious diseases
Interleukin 6
Kidney
Lupus anticoagulant
Lymphocyte count
Natriuretic peptide
Nervous
Nt probnp
Physiology
Platelet
Procalcitonin
Pulmonary
Sepsis
Serositis
Serum
Skin
Corresponding Organization :
Other organizations : Nanjing University, Nanjing General Hospital of Nanjing Military Command
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Variable analysis
independent variables
- Length of ICU stay
- History of SLE
- Renal biopsy pathology
- Organ damage (including skin, serositis, arthritis, heart, kidney, blood, central nervous and other system damage)
- Type and dose of immunosuppressants in the 2 months before ICU admission
- CD3+, CD4+, CD8+, CD20+ lymphocyte count
- Albumin
- Globulin
- Procalcitonin (PCT)
- Interleukin-6 (IL-6)
- Hemoglobin (Hgb)
- Platelet (PLT)
- N-terminal B-type natriuretic peptide (NT-proBNP)
- Serum creatinine (Scr)
- Blood urea nitrogen (BUN)
- Complement C3
- Complement C4
- Antinuclear antibody (ANA)
- Anti–double-stranded DNA antibody (anti-dsDNA)
- Anticardiolipin antibody (ACL)
- Lupus anticoagulant factor (LA)
- Proteinuria
- SLE Disease Activity Index (SLE-DAI)
- Acute Physiology and Chronic Health Assessment (APACHE) II scores
- Diagnosis of pulmonary infection and severe pulmonary infection
- Sepsis
- Positive controls: Not explicitly mentioned
- Negative controls: Not explicitly mentioned
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