Genetically Modified Mouse Models for Immunological Studies

Balb/c, C57BL/6, Rag1^−/− and Il1r1^−/− mice were purchased from Jackson Laboratory (Bar Harbor, ME). ST2^−/− (Il1rl1^−/−) (18 (link)), Il17rb^−/− (19 (link)), Tslpr^−/− (20 (link)), and Il13^+/eGFP mice (19 (link)) were generated on the Balb/c background and have been bred in the animal facility at the Mayo Clinic (Rochester, MN). Il5^+/venus mice (21 (link)) were a gift from Dr. Kiyoshi Takatsu (University of Toyama, Toyama, Japan). Six- to 12-week-old female mice were used in this study. All the experiments in this study were approved by the Mayo Clinic Institutional Animal Care and Use Committee.

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Iijima K., Kobayashi T., Hara K., Kephart G.M., Ziegler S.F., McKenzie A.N, & Kita H. (2014). IL-33 and Thymic Stromal Lymphopoietin Mediate Immune Pathology in Response to Chronic Airborne Allergen Exposure. Journal of immunology (Baltimore, Md. : 1950), 193(4), 1549-1559.

Publication 2014

Balb/c C57BL/6 Il1r1−/− mice

Animal Female Il13 Il1rl1 Institutional animal care and use committee Mice Rag1

Corresponding Organization : WinnMed

Other organizations : MRC Laboratory of Molecular Biology, Medical Research Council

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Variable analysis

independent variables

Genotype (Balb/c, C57BL/6, Rag1-/-, Il1r1-/-, ST2-/- (Il1rl1-/-), Il17rb-/-, Tslpr-/-, Il13+/eGFP, Il5+/venus)

dependent variables

Measured outcomes (not explicitly mentioned)

control variables

Age (six- to 12-week-old female mice)
Animal facility (Mayo Clinic, Rochester, MN)

controls

Positive control: Not specified
Negative control: Not specified

Annotations

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