A total of 486 psychiatric inpatients in Wuhan University of Science and Technology Affiliated Wuhan Hanyang Hospital from October 31, 2019, to October 31, 2020, were randomly selected, including 363 inpatients and 123 outpatients. There were 211 males and 275 females. The average age was (42.15 ± 5.02) years (range, 20–60 years).
Inclusion criteria: The diagnosis of schizophrenia met the International Classification of Diseases 10th edition criteria for schizophrenia,[5 ] and the diagnosis was confirmed by clinical manifestations and related imaging examinations; all the subjects completed systematic olanzapine treatment in our hospital; all the subjects had their first onset; did not take antipsychotic drugs or drugs affecting neurocognitive function before enrollment; the time from the first discovery of clinical symptoms of schizophrenia to this visit is <2 years; the patient’s medical records were kept intact, including baseline data and laboratory related indicators required for this study. Exclusion criteria: Positive And Negative Symptom Scale (PANSS)[6 (link)] ≤ 60 points; patients with previous brain trauma; patients with depression or mania; drugs that may affect autonomic nervous function, such as dopamine, antipyretic and analgesic drugs, were taken within 2 weeks after enrollment; allergic constitution patients; patients with alcohol addiction and other bad habits in the past. This study was reviewed and approved by the Ethics Board of Wuhan University of Science and Technology Affiliated Wuhan Hanyang Hospital.
Inclusion criteria: The diagnosis of schizophrenia met the International Classification of Diseases 10th edition criteria for schizophrenia,[5 ] and the diagnosis was confirmed by clinical manifestations and related imaging examinations; all the subjects completed systematic olanzapine treatment in our hospital; all the subjects had their first onset; did not take antipsychotic drugs or drugs affecting neurocognitive function before enrollment; the time from the first discovery of clinical symptoms of schizophrenia to this visit is <2 years; the patient’s medical records were kept intact, including baseline data and laboratory related indicators required for this study. Exclusion criteria: Positive And Negative Symptom Scale (PANSS)[6 (link)] ≤ 60 points; patients with previous brain trauma; patients with depression or mania; drugs that may affect autonomic nervous function, such as dopamine, antipyretic and analgesic drugs, were taken within 2 weeks after enrollment; allergic constitution patients; patients with alcohol addiction and other bad habits in the past. This study was reviewed and approved by the Ethics Board of Wuhan University of Science and Technology Affiliated Wuhan Hanyang Hospital.
