Example 5

Particle Size Distribution of Mifepristone Nano-Suspensions Used in Composition G and H:

TABLE 16
Process parameters of nano-milling for preparation of mifepristone
nano-suspensions used in composition G and H:
Nano-suspensionNano-suspension
used inused in
Parameterscomposition Gcomposition H
Mifepristone slurry20%20%
initial solid content
After rinsing of container15%15.8%  
bottle and mill
Due to additionalNA14.1%  
0.1 mm beads rinsing
Size of beads used 0.3 mm0.3 mm and 0.1 mm
Screen0.13 mm0.13 mm and 0.03 mm
Occupancy65%65%
Nano milling time90 minutes with 0.360 minutes with 0.3
mm beadsmm beads and
80 minutes with 0.1
mm beads
Particle Size Distribution (PSD) of mifepristone (in microns)
D100.0900.0602
D500.1860.122
D900.3690.233

TABLE 17
Effect of storage time on particle size distribution
of mifepristone in composition G
Particle Size Distribution (PSD) (in microns)
PSDInitialDay 1Day 3Day 7Day 15
D100.2840.2880.2700.2670.277
D500.3970.4040.3960.3940.404
D900.5490.5610.5830.5840.597

Free full text: Click here