Quantification of MBQ-167 in Tumors via SFC-MS/MS

We used a validated bioanalytical method using supercritical fluid chromatography coupled with tandem mass spectrometry to quantify MBQ-167 in tumors and tissues, as previously described [26 (link)]. The analysis was performed on an Acquity UPC² system (Waters Corp., Milford, MA, USA) coupled to a triple quadrupole tandem mass spectrometer (MS/MS). An Acquity UPC² BEH (3.0 × 100 mm², 1.7 μm) column was used for separation purposes.

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Reig-López J., Maldonado M.D., Merino-Sanjuan M., Cruz-Collazo A.M., Ruiz-Calderón J.F., Mangas-Sanjuán V., Dharmawardhane S, & Duconge J. (2020). Physiologically-Based Pharmacokinetic/Pharmacodynamic Model of MBQ-167 to Predict Tumor Growth Inhibition in Mice. Pharmaceutics, 12(10), 975.

Publication 2020

Acquity UPC2 system

Supercritical fluid chromatography Tandem mass spectrometry Tissues Tumors

Corresponding Organization : Universitat de València

Other organizations : University of Puerto Rico, Medical Sciences Campus

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Variable analysis

independent variables

Not explicitly mentioned

dependent variables

Concentration of MBQ-167 in tumors and tissues

control variables

Supercritical fluid chromatography coupled with tandem mass spectrometry method
Acquity UPC2 system (Waters Corp., Milford, MA, USA)
Acquity UPC2 BEH (3.0 × 100 mm2, 1.7 μm) column

controls

No positive or negative controls were explicitly mentioned in the given information.

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