Tuberculosis Recurrence Definitions

TB recurrence was defined as a patient who was cured or completed treatment during the most recent course of treatment and then was re-diagnosed with a new TB episode [World Health Organization (WHO), 2013 ]. Reinfection was defined as a recurrent disease episode caused by a new TB strain with a genetic distance of more than 12 SNPs compared with the strain that caused the original episode. Relapse was defined as a genetic distance of 12 or fewer SNPs between paired strains isolated from two episodes in TB recurrence (Li et al., 2022 (link)). The recurrent interval was defined as the time interval between the recorded end date of the initial TB treatment and the date of the re-diagnosis of active TB (Ruan et al., 2022 (link)). Based on the phenotypic drug susceptibility testing, Pan-Susceptible was defined as MTB strains that were susceptible to all anti-TB drugs tested in this study (including rifampicin, isoniazid, ethambutol, streptomycin, moxifloxacin, ofloxacin, kanamycin and amikacin), whereas Drug-resistant was defined as MTB strains that were resistant to at least one of these anti-TB drugs but not include the concurrent resistance to rifampicin and isoniazid. MDR-TB was defined as MTB resistance to at least isoniazid and rifampicin. Pre-XDR-TB was defined as MDR-TB with additional resistance to any fluoroquinolones (moxifloxacin or ofloxacin) or any second-line injectable drugs (amikacin or kanamycin), but not both. XDR-TB was defined as MDR-TB with additional resistance to any fluoroquinolones and any second-line injectable drugs.

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He W., Tan Y., Song Z., Liu B., Wang Y., He P., Xia H., Huang F., Liu C., Zheng H., Pei S., Liu D., Ma A., Cao X., Zhao B., Ou X., Wang S, & Zhao Y. (2023). Endogenous relapse and exogenous reinfection in recurrent pulmonary tuberculosis: A retrospective study revealed by whole genome sequencing. Frontiers in Microbiology, 14, 1115295.

Publication 2023

Amikacin Diagnosis Drugs Ethambutol Fluoroquinolones Genetic Isoniazid Kanamycin Moxifloxacin Ofloxacin Patient Phenotypic Reinfection Relapse Rifampicin Snps Strains Streptomycin Susceptibility Xdr tb

Corresponding Organization : Chinese Center For Disease Control and Prevention

Other organizations : National Institute for Communicable Disease Control and Prevention, Hunan Province Chest Hospital, Beijing Children’s Hospital, Capital Medical University, Peking University, Shenzhen Third People’s Hospital

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Variable analysis

independent variables

Recurrence type (reinfection or relapse)
Drug susceptibility (pan-susceptible, drug-resistant, MDR-TB, pre-XDR-TB, XDR-TB)

dependent variables

Recurrent interval (time interval between end of initial TB treatment and re-diagnosis of active TB)

control variables

None explicitly mentioned

controls

None explicitly mentioned

Annotations

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