Aluminum-Induced Neurodegeneration: Therapeutic Intervention

Rats were randomly divided into six experimental groups, each containing ten rats. Group I animals served as the normal control group, which received distilled water for 42 days. Group II was disease control and received aluminum chloride solution (100 mg/kg) for 42 days. Group III received aluminum chloride solution (100 mg/kg) and memantine (20 mg/kg) orally. Group IV received aluminum chloride solution (100 mg/kg) and baicalein (10 mg/kg) orally. Group V received an oral administration of aluminum chloride solution (100 mg/kg), memantine (20 mg/kg) and baicalein (5 mg/kg). Group VI was administered aluminum chloride solution (100 mg/kg), memantine (20 mg/kg) and baicalein (10 mg/kg) orally for 42 days. The dose of baicalein was selected based on the available literature (Zhou et al., 2016 (link)).