Olanzapine (5 mg, Sinophosphora H20052688, Jiangsu Hausen Pharmaceutical Group Co., LTD.), Olanzapine standard (20180723, Hunan Demeter Company), Org-deproteinizing agent (20180724, Hunan Demeter Company), Olanzapine plasma quality control product (high concentration, medium concentration, low concentration, 20180911, Hunan Demeter Company), Yibo Water (20180915, China Resources Yibo Beverage Co., LTD.). Instruments: Medical centrifuge (AXTG16G, Yancheng Anxin Experiment Co., LTD.), Medical centrifuge (AXTD5A, Yancheng Anxin Experiment Co., LTD.), Vortex mixer (XW-80A, Shanghai Chitang Electronics Co., LTD.), Medical refrigerated freezer (YCD-EL259A, ZhongKemiling Cryogenic Technology Co., LTD.), 1.5 mL centrifuge tube (Hunan Demeter Company), 1.5 mL deep well plate (Hunan Demeter Co., LTD.), and pipette gun (Eppendorf Research pLus, Germany).