Immunodeficient Duchenne Muscular Dystrophy Rat Model

We used the Wistar–Imamichi strain DMD rat model (DMD rat model: X^DmdY) carrying mutations in exons 3 and 16 of the Dmd gene (Nakamura et al., 2014 (link)). Immunodeficient F344/NJcl.Cg-Foxn1^rnu rats (nude rat: Foxn1^rnu/rnu) were purchased (CLEA Japan, Inc., Tokyo, Japan). Immunodeficient DMD rats were established by crossing a Foxn1^rnu/rnu male rat with an X^DmdX female rat. X^Dmd was identified by genotyping the litter population (Nakamura et al., 2014 (link)). The following rat genotypes were used in this study: X^DmdY Foxn1^rnu/rnu (DMD nude rats), XX Foxn1^rnu/rnu or XY Foxn1^rnu/rnu rats (WT nude rats) and X^DmdY Foxn1^rnu/+(immunocompetent DMD rat model).

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Sato M., Goto M., Yamanouchi K, & Sakurai H. (2023). A new immunodeficient Duchenne muscular dystrophy rat model to evaluate engraftment after human cell transplantation. Frontiers in Physiology, 14, 1094359.

Publication 2023

F344/NJcl.Cg-Foxn1rnu rats

Exons F344 rats Female Gene Genotypes Immunocompetent Immunodeficient Male Mutations Nude rats Strain Wistar rat

Corresponding Organization : Kyoto University

Other organizations : The University of Tokyo

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Variable analysis

independent variables

Genotypes of rats used in the study
Presence of immunodeficiency (Foxn1^rnu/rnu)

dependent variables

Not explicitly mentioned

control variables

Genetic background of the rat strains (Wistar–Imamichi strain, F344/NJcl.Cg-Foxn1^rnu)

controls

Positive control: X^Dmd^Y Foxn1^rnu/+ (immunocompetent DMD rat model)
Negative controls: XX Foxn1^rnu/rnu or XY Foxn1^rnu/rnu rats (WT nude rats)

Annotations

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