Demographic characteristics, medical history, anthropometrics, and self-reported dietary intake and physical activity were collected at the screening visit. During each of the 4 study visit periods, participants performed personal-level BC exposure monitoring for 5 consecutive days prior to the measurement of health responses. Study outcomes were performed fasting in the morning of each visit day and have been described in detail previously[14 (link), 25 (link)]. HRV was performed using the SpaceLabs EVO digital Holter system (SpaceLabs Healthcare, WA, USA). Aortic augmentation and carotid-femoral PWV determined by SphygmoCor CP device (AtCor Medical, Austrlia) and reactive hyperemial index (RHI) determined using peripheral arterial tonometry (EndoPAT2000, Itamar Medical, Israel). Supine BP was measured using the Omron HEM 907XL device. Fasting venous blood samples for plasma glucose, plasma insulin, lipoproteins, glycated hemoglobin, adiponectin and leptin was measured at PUMC. HOMA-IR was calculated using fasting insulin and glucose measures. Concomitant with day 4 of personal BC, 24-hour ambulatory BP levels was determined and reported previously[14 (link), 25 (link)].
Protocol detail
Comprehensive Cardiometabolic Assessment Protocol
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Adiponectin
Aortic
Arterial
Carotid
Device
Femoral
Glucose
Glucose blood
Glycated hemoglobin
Holter
Insulin
Leptin
Lipoproteins
Plasma
Tonometry
Venous
Corresponding Organization :
Other organizations : University of Maryland, Baltimore, Environment and Climate Change Canada, Peking Union Medical College Hospital, University of Michigan–Ann Arbor, Quality Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Tsinghua University, Lung Institute
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Variable analysis
independent variables
- Personal-level BC exposure monitoring for 5 consecutive days prior to the measurement of health responses
- Heart rate variability (HRV) measured using the SpaceLabs EVO digital Holter system
- Aortic augmentation and carotid-femoral pulse wave velocity (PWV) measured using the SphygmoCor CP device
- Reactive hyperemial index (RHI) measured using peripheral arterial tonometry (EndoPAT2000)
- Supine blood pressure measured using the Omron HEM 907XL device
- Fasting venous blood samples for plasma glucose, plasma insulin, lipoproteins, glycated hemoglobin, adiponectin and leptin measured at PUMC
- HOMA-IR calculated using fasting insulin and glucose measures
- 24-hour ambulatory blood pressure levels
- Demographic characteristics
- Medical history
- Anthropometrics
- Self-reported dietary intake and physical activity
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