Antimalarial Drug Potency Assessment

Chloroquine was purchased from Sigma-Aldrich. Dihydroartemisinin and piperaquine were kindly provided by Mangalam Drugs and Organics Ltd., Mumbai, India. Stock solutions of Chloroquine and piperaquine were prepared in distilled water, dihydroartemisinin in pure methanol (Merck, Darmstadt, Germany). Drug concentration ranges were chosen based on the average IC50 values available in the literature^{10 (link),29 (link)–33 (link),35 ,51 –54 (link)}. Doubling concentrations ranging from 6 to 100 nM for Chloroquine, and 6 to 486 nM for piperaquine, 0.12 to 32 nM for dihydroartemisinin were tested.

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Molnár P., Orbán Á., Izrael R., Babai R., Marton L., Butykai Á., Karl S., Vértessy B.G, & Kézsmárki I. (2020). Rapid and quantitative antimalarial drug efficacy testing via the magneto-optical detection of hemozoin. Scientific Reports, 10, 14025.

Publication 2020

Chloroquine pure methanol

Chloroquine Dihydroartemisinin Drug Methanol Piperaquine

Corresponding Organization :

Other organizations : Institute of Molecular Life Sciences, HUN-REN Research Centre for Natural Sciences, Budapest University of Technology and Economics, Australian Institute of Tropical Health and Medicine, James Cook University

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Variable analysis

independent variables

Chloroquine concentration
Dihydroartemisinin concentration
Piperaquine concentration

dependent variables

Not explicitly mentioned

control variables

Drug solvents (distilled water, pure methanol)
Drug concentration ranges based on literature

positive controls

Not specified

negative controls

Not specified

Annotations

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