Ancestry was determined using 10,000 randomly chosen markers with MAF>.05 by the program STRUCTURE 10 (link), 11 (link) which performs a Bayesian clustering analysis to assign subjects to ancestry groups (see additional details below). From this analysis, 491 individuals with a history of trauma exposure and valid genotype data were identified as having primarily white non-Hispanic ancestry, 84 were identified as having African American ancestry, and 105 were of “other” ancestry (including individuals self-described as having Hispanic, Native American, or Asian ancestry). We found no evidence of PTSD-associated population substructure within the VA-sample ancestry groups (see
Genetic Ancestry Analysis of PTSD in Veterans
Ancestry was determined using 10,000 randomly chosen markers with MAF>.05 by the program STRUCTURE 10 (link), 11 (link) which performs a Bayesian clustering analysis to assign subjects to ancestry groups (see additional details below). From this analysis, 491 individuals with a history of trauma exposure and valid genotype data were identified as having primarily white non-Hispanic ancestry, 84 were identified as having African American ancestry, and 105 were of “other” ancestry (including individuals self-described as having Hispanic, Native American, or Asian ancestry). We found no evidence of PTSD-associated population substructure within the VA-sample ancestry groups (see
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Corresponding Organization :
Other organizations : Boston University, Columbia University, Center for Human Genetics, National Center for PTSD, VA Boston Healthcare System, Wayne State University
Protocol cited in 11 other protocols
Variable analysis
- Ancestry (white non-Hispanic, African American, other)
- Lifetime diagnosis of PTSD based on the Clinician-Administered PTSD Scale (CAPS)
- Trauma exposure
- Gender
- No positive or negative controls were explicitly mentioned in the input.
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