Oxaliplatin was purchased from Tocris Bioscience (United Kingdom) and freshly dissolved in 5% glucose solution. For the acute Oxaliplatin model, mice received a single intraperitoneal administration of Oxaliplatin (6 mg/kg) or vehicle.4 (link) Tramadol hydrochloride (5 mg/kg, Sigma, Belgium) was prepared in a mixture of 1% hydroxypropylmethylcellulose HPMC/0.5% Tween 80 and administered through oral gavage. Isosakuranetin (2 mg/kg) was dissolved in Miglyol 812 (Caesar & Loretz GmbH, Hilden, Germany) containing 0.1% dimethyl sulfoxide (DMSO), and compounds or the vehicle alone were injected intraperitoneally. Primidone and PS were purchased from Sigma-Aldrich (Belgium) and dissolved in DMSO. Stock solutions were 20 mM and 100 mM, respectively.