Retrospective Analysis of LAH Outcomes

We retrieved data for 7535 FET cycles in the Reproductive and Genetic Center in the Affiliated Hospital of Shandong University of Traditional Chinese Medicine from January 2016 to December 2020. We included patients with D3 embryo transfer, transplantable embryos after thawing, and who had signed an informed consent prior to receiving LAH. Patients with blastocyst transfer (n = 577), chromosomal abnormalities (n = 89), thin endometrium (n = 67), uterine malformation (n = 156), endometriosis (n = 236), endocrine disease (such as diabetes, hypertension, and thyroid disease) (n = 357), and those with incomplete information on primary outcomes (n = 274) were excluded. The included cycles were categorized into LAH and non-LAH (NLAH) groups. The inclusion and exclusion procedures are shown in Fig. 1. The reproductive medicine ethics committee of the Affiliated Hospital of Shandong University of Traditional Chinese Medicine approved this study (no. SZ202109001).Fig. 1

Flowchart showing the selection of study population and matching by propensity score

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Wei C., Xiang S., Liu D., Wang C., Liang X., Wu H, & Lian F. (2023). Laser-assisted hatching improves pregnancy outcomes in frozen-thawed embryo transfer cycles of cleavage-stage embryos: a large retrospective cohort study with propensity score matching. Journal of Assisted Reproduction and Genetics, 40(2), 417-427.

Publication 2023

Blastocyst transfer Chromosomal abnormalities Diabetes Embryo transfer Embryos Endocrine disease Endometriosis Endometrium Hospital ethics committee Hypertension Patients Reproductive Thyroid disease Uterine malformation

Corresponding Organization :

Other organizations : Shandong University of Traditional Chinese Medicine, Affiliated Hospital of Shandong University of Traditional Chinese Medicine

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Variable analysis

independent variables

Receiving LAH (yes/no)

dependent variables

Ongoing pregnancy rate
Implantation rate

control variables

Patients with D3 embryo transfer
Patients with transplantable embryos after thawing
Patients who had signed an informed consent prior to receiving LAH
Exclusion criteria: blastocyst transfer, chromosomal abnormalities, thin endometrium, uterine malformation, endometriosis, endocrine disease (such as diabetes, hypertension, and thyroid disease)

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