The included participants were adults older than 18 years and had a diagnosis of primary nOH. nOH is widely categorized into primary and secondary types.15 (link) Primary nOH is associated with underlying neurological disorders involving the autonomic nervous system, including PD, MSA, DLB, and PAF.15 (link) Secondary nOH is associated with spinal cord disorders and peripheral neuropathies such as amyloidosis and diabetes mellitus.15 (link) To exclude patients with secondary nOH, we obtained individual line-level data from the authors of the relevant studies, including all causes of nOH, and excluded any data related to secondary nOH. Bedridden patients and those with contraindications to atomoxetine (e.g., coronary artery disease, abnormal liver function, and narrow-angle glaucoma) were also excluded.
Protocol detail
Primary Neurogenic Orthostatic Hypotension
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Adults
Atomoxetine
Autonomic nervous system
Bedridden patients
Coronary artery disease
Diabetes mellitus
Diagnosis
Narrow angle glaucoma
Neurological disorders
Neuropathies amyloidosis
Patients
Spinal cord disorders
Corresponding Organization :
Other organizations : Seoul St. Mary's Hospital, Daejeon St. Mary's Hospital, Catholic University of Korea, Chungbuk National University Hospital, Vanderbilt University, Chungbuk National University
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Variable analysis
independent variables
- None explicitly mentioned
- None explicitly mentioned
- Adults older than 18 years
- Diagnosis of primary nOH
- Exclusion of patients with secondary nOH
- Exclusion of bedridden patients
- Exclusion of patients with contraindications to atomoxetine (e.g., coronary artery disease, abnormal liver function, and narrow-angle glaucoma)
- Positive control: None mentioned
- Negative control: None mentioned
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