In Beijing, 15 community health centers were selected by multistage random sampling approach. People with type 2 diabetes (aged 20–80 years) who had lived in the community over 5 years were recruited between August 2008 and July 2009. A total of 3,182 diabetic subjects with measurement of NC were available for analysis. People with severe disabilities, hepatic failure, renal failure, schizophrene, or goiter were excluded. Written informed consent was obtained from all participants.
Past medical history was determined with a standardized questionnaire. Blood pressure was measured twice after each subject had been seated for 10 min. The average was used for analysis. Waist circumference (WC) was measured at the level midway between the lower rib margin and the iliac crest. NC was measured with head erect and eyes facing forward, horizontally at the upper margin of the laryngeal prominence (Adam's apple). Fasting glucose and lipid profiles were determined using an autoanalyzer.
Overweight was defined as BMI ≥24 kg/m2, central obesity was defined as WC ≥85 cm for men and ≥80 cm for women (5 –6 ). MS was defined according to the Chinese Diabetes Society definition (7 ).
Receiver operating characteristic (ROC) curve analyses were performed using SPSS 11.5 software. The Youden index, defined as “sensitivity + specificity − 1,” was used to determine the optimal NC cutoff points.