Lung Parenchyma Quantification Protocol

HRCT were performed at 10 mm section interval (120 kV, 50–450 mAs), (1 mm slice thickness, 1.5s scanning time) with a window level between 2550 and 40 Hounsfield Units (HU) and window width between 300 and 1600 HU using the Toshiba Aquilion 64 CT Scanner (Toshiba, Tokyo, Japan). HRCT scans were analyzed two independent chest radiologists and final conclusions on the findings were reached by consensus. The arbitrary scores were based on the percentage of lung parenchyma abnormality as previously described [36] (link), [37] (link).

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Zhang G., Zhou B., Li S., Yue J., Yang H., Wen Y., Zhan S., Wang W., Liao M., Zhang M., Zeng G., Feng C.G., Sassetti C.M, & Chen X. (2014). Allele-Specific Induction of IL-1β Expression by C/EBPβ and PU.1 Contributes to Increased Tuberculosis Susceptibility. PLoS Pathogens, 10(10), e1004426.

Publication 2014

Aquilion 64 CT Scanner

Chest Ct scanner Lung Radiologists Scans

Corresponding Organization :

Other organizations : Guangdong Medical College, Sun Yat-sen University, Tongji University, Jinan University, University of Sydney, University of Massachusetts Chan Medical School

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Variable analysis

independent variables

Section interval (10 mm)
Voltage (120 kV)
Tube current (50–450 mAs)
Slice thickness (1 mm)
Scanning time (1.5s)

dependent variables

Percentage of lung parenchyma abnormality

control variables

Window level (2550 and 40 Hounsfield Units (HU))
Window width (300 and 1600 HU)
CT scanner (Toshiba Aquilion 64 CT Scanner)

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