Eligible patients had a smear-positive fungal corneal ulcer and baseline visual acuity of 20/40 (0.3 logMAR) to 20/400 (1.3 logMAR) (Table 1 ). Reasons for exclusion included impending perforation, evidence of bacterial, Acanthamoeba, or herpetic keratitis, being younger than 16 years, and bilateral ulcers or visual acuity worse than 20/200 (1.0 logMAR) in the nonaffected eye. Masked assignment to the treatment intervention was performed after determination of eligibility and consent to participate. Enrollment centers included the Aravind Eye Care System in India (Madurai, Pondicherry, and Coimbatore) and the Francis I. Proctor Foundation, University of California, San Francisco.
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Fungal Corneal Ulcer Treatment Protocol
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Acanthamoeba
Bacterial
Corneal ulcer
Eligibility determination
Herpetic keratitis
Patients
Than
Ulcers
Visual acuity
Younger
Corresponding Organization :
Other organizations : Aravind Eye Hospital
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Variable analysis
independent variables
- Treatment intervention
- Baseline visual acuity
- Eligibility criteria (smear-positive fungal corneal ulcer, baseline visual acuity of 20/40 (0.3 logMAR) to 20/400 (1.3 logMAR))
- Exclusion criteria (impending perforation, evidence of bacterial, Acanthamoeba, or herpetic keratitis, being younger than 16 years, and bilateral ulcers or visual acuity worse than 20/200 (1.0 logMAR) in the nonaffected eye)
- Positive control: Not explicitly mentioned.
- Negative control: Not explicitly mentioned.
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