Standardized Assessment of Metabolic and Functional Parameters
At enrollment and at each time-point, metabolic and functional parameters (i.e. glucose, insulin, lipid profile, liver and renal function) were assessed by a standardized validated protocol, using an automatic biochemical analyzer (ILAB 650, Instrumentation Laboratory, Lexington, MA). Low density lipoprotein cholesterol (LDL-C) concentration was estimated using the Friedewald formula [33 (link)], while non-high density lipoprotein cholesterol (non-high density lipoprotein-cholesterol, HDL-C) was calculated by subtracting HDL-C from total cholesterol (TC). The HOMA-Index and Cockroft-Gault index were calculated according to the relevant formula [34 (link), 35 (link)].
Guglielmetti S., Bernardi S., Del Bo’ C., Cherubini A., Porrini M., Gargari G., Hidalgo-Liberona N., Gonzalez-Dominguez R., Peron G., Zamora-Ros R., Winterbone M.S., Kirkup B., Kroon P.A., Andres-Lacueva C, & Riso P. (2020). Effect of a polyphenol-rich dietary pattern on intestinal permeability and gut and blood microbiomics in older subjects: study protocol of the MaPLE randomised controlled trial. BMC Geriatrics, 20, 77.
Other organizations :
University of Milan, Istituti di Ricovero e Cura a Carattere Scientifico, Istituto Nazionale di Riposo e Cura per Anziani, Universitat de Barcelona, Quadram Institute, Norwich Research Park, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable
Non-high density lipoprotein cholesterol (non-HDL-C)
HOMA-Index
Cockroft-Gault index
control variables
Metabolic and functional parameters were assessed using a standardized validated protocol
Automatic biochemical analyzer (ILAB 650, Instrumentation Laboratory, Lexington, MA) was used
LDL-C concentration was estimated using the Friedewald formula
Non-HDL-C was calculated by subtracting HDL-C from total cholesterol (TC)
HOMA-Index and Cockroft-Gault index were calculated according to the relevant formula
positive controls
None explicitly mentioned
negative controls
None explicitly mentioned
Annotations
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