We conducted parallel GWAS in nine samples of European ancestry and combined the results via meta-analysis. We applied two phenotypic strategies aimed at capturing common (pleiotropic) genetic effects shared across the five core ADs: GAD, PD, social phobia, agoraphobia, and specific phobias. We conducted two types of analyses in each sample based upon complementary approaches to modeling the comorbidity and common genetic risk across the ADs: (1) case-control (CC) comparisons, in which cases were designated as having “any AD” versus supernormal controls, and (2) quantitative factor scores (FS) estimated for every subject in the sample using confirmatory factor analysis.
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Genome-wide study of anxiety disorders
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Other organizations : Virginia Commonwealth University, Erasmus MC, QIMR Berghofer Medical Research Institute, Washington DC VA Medical Center, University of Colorado Boulder, University of Lausanne, Universitätsmedizin Greifswald, Universität Greifswald, GGZ inGeest, University of Queensland, Washington University in St. Louis, University Medical Center Groningen, University of Groningen, Erasmus MC - Sophia Children’s Hospital, EMGO Institute for Health and Care Research, Johns Hopkins University
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- Parallel GWAS in nine samples of European ancestry
- Two phenotypic strategies aimed at capturing common (pleiotropic) genetic effects shared across the five core ADs: GAD, PD, social phobia, agoraphobia, and specific phobias
- Two types of analyses in each sample based upon complementary approaches to modeling the comorbidity and common genetic risk across the ADs: (1) case-control (CC) comparisons, in which cases were designated as having "any AD" versus supernormal controls, and (2) quantitative factor scores (FS) estimated for every subject in the sample using confirmatory factor analysis
- Genetic effects shared across the five core ADs: GAD, PD, social phobia, agoraphobia, and specific phobias
- Supernormal controls
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